optimization of O/W emulsions by a safe and effective fatty acid ester
The fact:
Xalifin-15 is the only vehiculant bioemulgoid O/W at high stability and releasing capability
Registrations
trade name
Xalifin-15
sole manufacturer
Vevy Europe S.p.A.
vevy codex
02.0151
trademark and patent
1959
INCI name
C12-C20 Acid PEG-8 Ester
CAS No
68908-68-9, 68334-02-1, 5117-19-1
FDA CRMCS No
R-00114867
EINECS No
269-807-5, 225-856-4
JAPAN
MHW 372
DIIC No
339200
Specifications
appearance
paste
odour
light characteristic
colour
white ivory
solubility
lipidic systems
melting
point 33°C-46°C
Ethylene oxide
none
acid value
max 0.9
iodine value [Wijs]
< 5
saponification value
70 - 90
Properties
O/W Emulsifier
Non ionic
HLB=12
Safe: 1,4 Dioxane free
Excellent Stability
Excellent Release Ability
Excellent Texture
Excellent Spreadability
High Skin Feel Index
Applications
Cosmetic creams
Lotions
Topical pharmaceuticals
Toxicology
Acute Toxicity
LD 50 i.p. in Mice 1.76 g/kg
Subacute Toxicity
Non Toxic When Tested at 1/10 of LD 50
Chronic Toxicity
Non Toxic
Draize Test
Non Irritant When Tested at 10% Dilution
Primary Acute Irritancy Index
0 (100%), Ranging from 0 to 8
Primary Subacute Irritancy Index (Fatigue Test)
Non Irritant
Teratogenic Activity
Non Teratogenic
Potential Carcinogenic Activity
Devoid of PCA
Guinea Pig Sensitizing Activity
No Delayed Ipersensivity Reaction
Human Sensitizing Activity (Patch Test)
Negative
Mutagenesis (Ames Test)
Negative
Enzymotoxicity
% of Normal Enzymatic Activity in presence of Xalifin-15
EC.2.6.1.2=100
EC.2.7.1.12=100
EC.2.6.1.1=100
EC.5.3.1.9=100
EC.1.4.1.2=100
EC.2.7.5.1=100
EC.1.1.1.37=100
EC.4.1.2.13=100
EC.1.1.1.27=100
EC.1.1.1.49=100
EC.1.1.1.42=100
